Send to:

Choose Destination
See comment in PubMed Commons below
Org Lett. 2014 Mar 21;16(6):1550-3. doi: 10.1021/ol500474a. Epub 2014 Mar 6.

Catalytic asymmetric exo-selective [C+NC+CC] reaction.

Author information

  • 1Department of Chemistry, Washington State University , Pullman, Washington 99164-4630, United States.


A catalytic asymmetric version of the exo-selective [C+NC+CC] reaction is reported. This multicomponent reaction utilizes a readily prepared achiral glycyl sultam as the "NC" component and commercially available catalyst components. The method can be applied to a variety of aldehydes ("C" component) and activated alkenes ("CC" component) to provide substituted pyrrolidines in good yields and high enantioselectivities. Of particular note is the ability to employ labile enolizable aldehydes (e.g., acetaldehyde and propionaldehyde) in this reaction.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk