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Nat Prod Res. 2014;28(9):680-2. doi: 10.1080/14786419.2014.891591. Epub 2014 Mar 5.

Pelopuradazole, a new imidazole derivative alkaloid from the marine bacteria Pelomonas puraquae sp. nov.

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  • 1a School of Chinese Materia Medica, Guangzhou University of Chinese Medicine , 232 Waihuan East Road, Guangzhou 510006 , P.R. China.


One new imidazole derivative alkaloid pelopuradazole (1), together with three known alkaloids as in 3H-imidazole-4-carboxylic acid (2), 1H-pyrrole-2-carboxylic acid (3) and 2-methyl-3H-imidazole-4-carboxylic acid (4) and two known cyclo-dipeptides pelopurin A (5) and pelopurin B (6), has been isolated from the marine bacterium Pelomonas puraquae sp. nov. Pelopuradazole (1) was a new imidazole derivative alkaloid, while compounds 2, 3, 5 and 6 were firstly obtained as natural products. Compounds 1-6 were isolated from P. puraquae sp. nov. for the first time.


Pelomonas puraquae sp. nov.; Pelopuradazole; alkaloid; cyclic dipeptide; marine bacteria

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