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Angew Chem Int Ed Engl. 2014 Apr 7;53(15):3993-5. doi: 10.1002/anie.201311192. Epub 2014 Mar 5.

Ubiquinone-rhodol (UQ-Rh) for fluorescence imaging of NAD(P)H through intracellular activation.

Author information

  • 1MANA, National Institute for Materials Science, 1-1 Namiki, Tsukuba-city, Ibaraki, 305-0044 (Japan). KOMATSU.Hirokazu@nims.go.jp.

Abstract

The nicotinamide adenine dinucleotide (NAD) derivatives NADH and NADPH are critical components of cellular energy metabolism and operate as electron carriers. A novel fluorescent ubiquinone-rhodol derivative (UQ-Rh) was developed as a probe for NAD(P)H. By using the artificial promoter [(η(5) -C5 Me5 )Ir(phen)(H2 O)](2+) , intracellular activation and imaging of NAD(P)H were successfully demonstrated. In contrast to bioorthogonal chemistry, this "bioparallel chemistry" approach involves interactions with native biological processes and could potentially be used to control or investigate cellular systems.

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

NAD(P)H; fluorescent probes; imaging agents; in vivo imaging; redox chemistry

PMID:
24596071
[PubMed - in process]
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