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Eur J Med Chem. 2014 Apr 9;76:291-300. doi: 10.1016/j.ejmech.2014.02.013. Epub 2014 Feb 11.

Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents.

Author information

  • 1Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
  • 2Universidade Federal de Pernambuco, Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil.
  • 3Universidade Federal de Pernambuco, Departamento de Antibióticos, Cidade Universitária, Recife, PE, Brazil.
  • 4Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil. Electronic address: paulo.menezes@pq.cnpq.br.

Abstract

(-)-Massoialactone, an α,β-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.

Copyright © 2014 Elsevier Masson SAS. All rights reserved.

KEYWORDS:

Anti-inflammatory activity; Antitumoral activity; Lactones; Massoialactone; Tellurides

PMID:
24589485
[PubMed - indexed for MEDLINE]
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