Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2014 Feb 24;9(2):e89455. doi: 10.1371/journal.pone.0089455. eCollection 2014.

Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training.

Author information

  • 1Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self Defense Force, Setagaya, Setagaya, Tokyo, Japan ; Department of Psychiatry, Japan Self-Defense Force Central Hospital, Setagaya, Setagaya, Tokyo, Japan.
  • 2Department of Defense Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • 3Department of Psychiatry, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • 4Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self Defense Force, Setagaya, Setagaya, Tokyo, Japan.
  • 5Department of Internal medicine, Japan Self-Defense Force Central Hospital, Setagaya, Setagaya, Tokyo, Japan.
  • 6Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
  • 7Division of Behavioral Sciences, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan.

Abstract

Decreased concentrations of plasma brain-derived neurotrophic factor (BDNF) and serum BDNF have been proposed to be a state marker of depression and a biological indicator of loaded psychosocial stress. Stress evaluations of participants in military mission are critically important and appropriate objective biological parameters that evaluate stress are needed. In military circumstances, there are several problems to adopt plasma BDNF concentration as a stress biomarker. First, in addition to psychosocial stress, military missions inevitably involve physical exercise that increases plasma BDNF concentrations. Second, most participants in the mission do not have adequate quality or quantity of sleep, and sleep deprivation has also been reported to increase plasma BDNF concentration. We evaluated plasma BDNF concentrations in 52 participants on a 9-week military mission. The present study revealed that plasma BDNF concentration significantly decreased despite elevated serum enzymes that escaped from muscle and decreased quantity and quality of sleep, as detected by a wearable watch-type sensor. In addition, we observed a significant decrease in plasma vascular endothelial growth factor (VEGF) during the mission. VEGF is also neurotrophic and its expression in the brain has been reported to be up-regulated by antidepressive treatments and down-regulated by stress. This is the first report of decreased plasma VEGF concentrations by stress. We conclude that decreased plasma concentrations of neurotrophins can be candidates for mental stress indicators in actual stressful environments that include physical exercise and limited sleep.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk