Alkali myosin light chains in man are encoded by a...[Gene. 1988]

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1: Gene. 1988 Jun 15;66(1):135-46. Links

Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms.

Seidel U, Bober E, Winter B, Lenz S, Lohse P, Goedde HW, Grzeschik KH, Arnold HH.

Department of Toxicology, Medical School, University of Hamburg, F.R.G.

A set of cDNA clones coding for alkali myosin light chains (AMLC) was isolated from fetal human skeletal muscle. Nucleotide sequence analysis and RNA expression patterns of individual clones revealed related sequences corresponding to (i) fast fiber type MLC1 and MLC3; (ii) the embryonic MLC that is also expressed in fetal ventricle and adult atrium (MLCemb); and (iii) a nonsarcomeric MLC isoform that is found in all nonmuscle cell types and smooth muscle. The AMLC gene family in man comprises unique copies for MLC1, MLC3 and MLCemb, and multiple copies for the nonsarcomeric MLC genes. The gene coding for MLC1 and MLC3 is located on human chromosome 2.

PMID: 2458299 [PubMed - indexed for MEDLINE]

Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle.
J Biol Chem. 1989 Sep 25; 264(27):16109-17.

[J Biol Chem. 1989]
A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria.
Eur J Biochem. 1988 Dec 1; 178(1):53-60.

[Eur J Biochem. 1988]
The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways.
J Biol Chem. 1989 May 25; 264(15):9009-15.

[J Biol Chem. 1989]
ReviewMyosin II isoforms in smooth muscle: heterogeneity and function.
Am J Physiol Cell Physiol. 2007 Aug; 293(2):C493-508. Epub 2007 May 2.

[Am J Physiol Cell Physiol. 2007]
Review[Myosin isoforms of skeletal muscles in development]
Ontogenez. 1987 Nov-Dec; 18(6):573-86.

[Ontogenez. 1987]
» See reviews... | » See all...

Cited by 3 PubMed Central articles

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.
Braun T, Buschhausen-Denker G, Bober E, Tannich E, Arnold HH. EMBO J. 1989 Mar; 8(3):701-9.

[EMBO J. 1989]
A novel isoform of myosin alkali light chain isolated from human muscle cells.
Zimmermann K, Starzinski-Powitz A. Nucleic Acids Res. 1989 Dec 25; 17(24):10496.

[Nucleic Acids Res. 1989]
Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
Braun T, Bober E, Winter B, Rosenthal N, Arnold HH. EMBO J. 1990 Mar; 9(3):821-31.

[EMBO J. 1990]

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Cited by 3 PubMed Central articles

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