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Indian Heart J. 2014 Jan-Feb;66(1):104-7. doi: 10.1016/j.ihj.2013.12.003. Epub 2013 Dec 26.

Brugada syndrome with a novel missense mutation in SCN5A gene: a case report from Bangladesh.

Author information

  • 1Assistant Professor, Department of Cardiology, Rajshahi Medical College, Rajshahi 6000, Bangladesh. Electronic address: zahidus.sayeed@yahoo.com.
  • 2Associate Professor, Department of Microbiology, Rajshahi Medical College, Rajshahi 6000, Bangladesh.
  • 3Assistant Professor, Department of Medicine, Rajshahi Medical College, Rajshahi 6000, Bangladesh.
  • 4Registrar, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka 1205, Bangladesh.

Abstract

Brugada syndrome is an inherited cardiac arrhythmia that follows autosomal dominant transmission and can cause sudden death. We report a case of Brugada syndrome in a 55-year-old male patient presented with recurrent palpitation, atypical chest pain and presyncope. ECG changes were consistent with type 1 Brugada. Gene analysis revealed a novel missense mutation in SCN5A gene with a genetic variation of D785N and a nucleotide change at 2353G-A. One of his children also had the same mutation. To our knowledge this is the first genetically proved case of Brugada syndrome in Bangladesh.

Copyright © 2013 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

KEYWORDS:

Bangladesh; Brugada syndrome; Novel missense mutation; SCN5A gene

PMID:
24581105
[PubMed - in process]
PMCID:
PMC3946469
Free PMC Article

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