Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mult Scler. 2014 Sep;20(10):1348-54. doi: 10.1177/1352458514525867. Epub 2014 Feb 26.

Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years.

Author information

  • 1Department of Neurology, University Hospital Basel, Switzerland.
  • 2Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Switzerland.
  • 3Department of Radiology, University Hospital Basel, Switzerland.
  • 4Department of Radiology, University Hospital Basel, Switzerland Medical Image Analysis Centre, University Hospital Basel, Switzerland.
  • 5Department of Neurology, University Hospital Basel, Switzerland University of Basel, Switzerland.
  • 6Department of Neurology, University Hospital Basel, Switzerland University of Basel, Switzerland Peter.Fuhr@usb.ch.

Abstract

BACKGROUND:

The development of predictors of multiple sclerosis (MS) disability is difficult due to the complex interplay of pathophysiological and adaptive processes.

OBJECTIVE:

The purpose of this study was to investigate whether combined evoked potential (EP)-measures allow prediction of MS disability after 20 years.

METHODS:

We examined 28 patients with clinically definite MS according to Poser's criteria with Expanded Disability Status Scale (EDSS) scores, combined visual and motor EPs at entry (T0), 6 (T1), 12 (T2) and 24 (T3) months, and a cranial magnetic resonance imaging (MRI) scan at T0 and T2. EDSS testing was repeated at year 14 (T4) and year 20 (T5). Spearman rank correlation was used. We performed a multivariable regression analysis to examine predictive relationships of the sum of z-transformed EP latencies (s-EPT0) and other baseline variables with EDSST5.

RESULTS:

We found that s-EPT0 correlated with EDSST5 (rho=0.72, p<0.0001) and ΔEDSST5-T0 (rho=0.50, p=0.006). Backward selection resulted in the prediction model: E (EDSST5)=3.91-2.22×therapy+0.079×age+0.057×s-EPT0 (Model 1, R (2)=0.58) with therapy as binary variable (1=any disease-modifying therapy between T3 and T5, 0=no therapy). Neither EDSST0 nor T2-lesion or gadolinium (Gd)-enhancing lesion quantities at T0 improved prediction of EDSST5. The area under the receiver operating characteristic (ROC) curve was 0.89 for model 1.

CONCLUSIONS:

These results further support a role for combined EP-measures as predictors of long-term disability in MS.

© The Author(s) 2014.

KEYWORDS:

Evoked potentials; magnetic resonance imaging; multiple sclerosis; prognosis

PMID:
24574192
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk