Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nephrology (Carlton). 2014 May;19(5):282-7. doi: 10.1111/nep.12221.

Epidemiology and outcome of community-acquired acute kidney injury.

Author information

  • 1Insititute of Nephrology, Cardiff University School of Medicine, Cardiff, UK.

Abstract

AIMS:

Very little data exist regarding community-acquired acute renal injury (CA-AKI). We have identified and characterized a patient cohort with CA-AKI, and documented its impact on renal function and patient mortality.

METHODS:

Using the database of the Medical Biochemistry Department of the Cardiff and Vale University Health Board we identified all patients with CA-AKI over a 1 month period in 2009. Follow-up biochemical and clinical data were used to determine short-term (3 months) and long-term (3 years) outcomes. Comparisons were made to a random and an age/sex matched group.

RESULTS:

Patients with CA-AKI were older than a non-AKI cohort (70.3 vs 57.1 years; P < 0.0001), with a 61% male predominance. 38% had pre-existing chronic kidney disease (CKD) compared with 25% in the age- and sex-matched non-CA-AKI cohort (P = 0.007). 54% of CA-AKI were admitted for inpatient care. Admission was associated with a higher incidence of complete recovery of renal function. Mortality at 3 months was 16.5%, and was related to the severity of AKI. Over the 3 years of follow-up 71% of patients with CA-AKI developed progressive CKD which was more likely following incomplete/no recovery of renal function and in the context of pre-existing CKD. Three year mortality was 45%, which was higher than that of the age/sex matched control cohort (15.7%; P < 0.0001), but was not related to the development of progressive CKD.

CONCLUSIONS:

CA-AKI carries significant implications in terms of both development of progressive renal disease and high long-term patient mortality.

© 2014 Asian Pacific Society of Nephrology.

KEYWORDS:

acute renal failure; clinical epidemiology; clinical nephrology; epidemiology

PMID:
24571827
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk