How do we prepare the nursing and health workforce of the future to meet the challenges of the US health system and equip graduates with problem-solving strategies that are scientific, compassionate, and agile? This article provides examples of several approaches for nursing health professions education, including innovation, interprofessionalism, and multiple, simultaneous community collaboratives. Specific examples highlight ways academic nursing programs and practice organizations are working together to provide stimulating, realistic, safe, and effective education while exposing students to the challenges inherent in the health system.