Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2014 Mar 3;124(3):978-80. doi: 10.1172/JCI74417. Epub 2014 Feb 24.

PPARγ in emphysema: blunts the damage and triggers repair?


Cigarette smoke is the most common cause of pulmonary emphysema, which results in an irreversible loss of lung structure and function. Th1 and Th17 immune responses have been implicated in emphysema pathogenesis; however, the drivers of emphysema-associated immune dysfunction are not fully understood. In this issue of the JCI, Shan and colleagues found that peroxisome proliferator-activated receptor γ (PPARγ) is downregulated in APCs isolated from the lungs of emphysematous chronic smokers and mice exposed to cigarette smoke. Furthermore, treatment with a PPARγ agonist prevented emphysema development and appeared to reduce emphysema-associated lung volume expansion in mice exposed to cigarette smoke. Further work will need to be done to evaluate the potential of PPARγ agonists to restore lung capacity in emphysematous patients.

Comment on

[PubMed - indexed for MEDLINE]
[Available on 2015/1/1]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Journal of Clinical Investigation
    Loading ...
    Write to the Help Desk