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Res Vet Sci. 2014 Apr;96(2):251-3. doi: 10.1016/j.rvsc.2014.02.004. Epub 2014 Feb 11.

Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates.

Author information

  • 1BioNano Laboratory, School of Engineering, University of Guelph, Guelph N1G 2W1, Canada.
  • 2Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada.
  • 3BioNano Laboratory, School of Engineering, University of Guelph, Guelph N1G 2W1, Canada. Electronic address: sneethir@uoguelph.ca.
  • 4Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada.

Abstract

The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.

Copyright © 2014 Elsevier Ltd. All rights reserved.

KEYWORDS:

Fosfomycin; MRSP; Methicillin-resistant; Staphylococcus pseudintermedius; fosB

PMID:
24569298
[PubMed - indexed for MEDLINE]
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