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Nat Genet. 2014 Mar;46(3):217-8. doi: 10.1038/ng.2902.

Stem cell fate regulation by dynein motor protein Lis1.

Author information

  • 1Department of Cell Biology and the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, New York, USA.
  • 2Department of Cell Biology, the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, the Department of Medicine (Oncology) and the Albert Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York, USA.

Abstract

Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor-regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

PMID:
24569235
[PubMed - indexed for MEDLINE]
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