Medulloblastoma in association with the Coffin-Siris syndrome

Childs Nerv Syst. 1988 Feb;4(1):41-4. doi: 10.1007/BF00274083.

Abstract

An 8-year old patient with Coffin-Siris syndrome is presented, who was found to have a medulloblastoma during the evaluation of apnea and ventilator dependency. Although several cases of Dandy Walker cysts and one case of brain-stem heterotopia have been described in this rare syndrome, this is the first report of medulloblastoma in a patient with Coffin-Siris syndrome. Possible pathogenetic mechanisms are briefly discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / complications*
  • Brain Neoplasms / complications*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology
  • Child
  • Cranial Fossa, Posterior
  • Developmental Disabilities / complications*
  • Female
  • Fingers / abnormalities
  • Humans
  • Intellectual Disability / complications*
  • Joint Diseases / complications*
  • Medulloblastoma / complications*
  • Medulloblastoma / diagnostic imaging
  • Medulloblastoma / pathology
  • Nails, Malformed
  • Radiography
  • Syndrome
  • Toes / abnormalities