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J Reprod Med. 2013 Nov-Dec;58(11-12):511-6.

Effect of vitamin D on postoperative adhesion formation in a rat uterine horn adhesion model.

Author information

  • 1Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey. saynur77@yahoo.com
  • 2Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.

Abstract

OBJECTIVE:

To determine the role of vitamin D for preventing or reducing postoperative adhesions.

STUDY DESIGN:

The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters.

RESULTS:

Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p < 0.05). On the other hand, no difference was detected between the groups according to the fibrosis score.

CONCLUSION:

Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.

PMID:
24568046
[PubMed - indexed for MEDLINE]
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