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Chem Commun (Camb). 2014 Apr 7;50(27):3575-8. doi: 10.1039/c4cc00103f. Epub 2014 Feb 24.

A facile mechanophore functionalization of an amphiphilic block copolymer towards remote ultrasound and redox dual stimulus responsiveness.

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  • 1State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.


Two different site-specific cleavage mechanisms for copolymer micelles under ultrasound and redox were confirmed. The finding that ultrasound induced mechanochemical cleavage of central ester bonds can open up a new way in the design of novel ultrasound responsive copolymer micelles for drug release.

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