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Analyst. 2014 Apr 21;139(8):1834-8. doi: 10.1039/c3an02269b.

Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex.

Author information

  • 1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P. R. China. xcweng@whu.edu.cn xzhou@whu.edu.cn.

Erratum in

  • Analyst. 2014 Sep 7;139(17):4382. Lai, Hai [corrected to Lai, Han].


In this study, we present a fluorescent switch-on probe based on a cyanovinyl-pyridinium triphenylamine (CPT) derivative that exhibited a 190-fold increase in fluorescence upon binding to G-quadruplex-forming oligonucleotide 22AG. This probe showed specificity and selectivity towards an antiparallel G-quadruplex, indicating its promising potential in G-quadruplex imaging.

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