Send to:

Choose Destination
See comment in PubMed Commons below
J Crohns Colitis. 2014 Sep;8(9):1030-42. doi: 10.1016/j.crohns.2014.01.028. Epub 2014 Feb 21.

Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with inflammatory bowel disease--an ECCO-EpiCom study.

Author information

  • 1Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark. Electronic address:
  • 2Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
  • 3Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
  • 4Nicosia Private Practice, Nicosia, Cyprus.
  • 5IBD Center ISCARE, Charles University, Prague, Czech Republic.
  • 6Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
  • 7Department of Medicine, Amager Hospital, Amager, Denmark.
  • 8Department of Medicine, Herning Central Hospital, Herning, Denmark.
  • 9Medical Department, Viborg Regional Hospital, Viborg, Denmark.
  • 10Medical Department, Viborg Regional Hospital, Viborg, Denmark; Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
  • 11Department of Medicine V, Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
  • 12Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark.
  • 13Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia.
  • 14Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
  • 15Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
  • 161st Division of Internal Medicine and Division of Gastroenterology, Medical School, University of Ioannina, Ioannina, Greece.
  • 17Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland.
  • 18Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary.
  • 19Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland.
  • 20Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
  • 21Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel; Department of Gastroenterology and Hepatology, Ben Gurion University of the Negev, Beer Sheva, Israel.
  • 22U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni - Pierantoni, Forlì, Italy; On behalf of the EpiCom Northern Italy centre based in Crema & Cremona, Firenze, Forlì, Padova and Reggio Emilia, Italy.
  • 23U.O. Medicina 3° e Gastroenterologia, Azienda Ospedaliera Arcispedale S. Maria Nuova, Reggio Emilia, Italy; On behalf of the EpiCom Northern Italy centre based in Crema & Cremona, Firenze, Forlì, Padova and Reggio Emilia, Italy.
  • 24Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • 25Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
  • 26Hospital de Vale de Sousa, Porto, Portugal.
  • 27Department of Gastroenterology, Hospital São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal; IBMC - Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
  • 28Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
  • 29Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
  • 30Gastroenterology Department, POVISA Hospital, Vigo, Spain.
  • 31Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
  • 32Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Gastroenterology/UHL, County Council of Östergötland, Linköping, Sweden.
  • 33Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
  • 34Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
  • 35St. Mark's Hospital, Imperial College London, London, UK.
  • 36Hull and East Yorkshire NHS Trust & Hull and York Medical School, Hull Royal Infirmary, Hull, UK; Hull and York Medical School, Hull Royal Infirmary, Hull, UK.
  • 371st Department of Medicine, Semmelweis University, Budapest, Hungary.
  • 38Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.



Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.


The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.


In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.


Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.


Disease course; Epidemiology;; Inception cohort;; Quality of life;

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk