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Fertil Steril. 2014 May;101(5):1419-23. doi: 10.1016/j.fertnstert.2014.01.035. Epub 2014 Feb 19.

Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome.

Author information

  • 1Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; Center for Reproductive Medicine, Central Hospital, Taian, People's Republic of China.
  • 2Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
  • 3Taishan Medical College, Taian, People's Republic of China.
  • 4Center for Reproductive Medicine, Central Hospital, Taian, People's Republic of China.
  • 5Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China. Electronic address: shiyuhua2003@126.com.

Abstract

OBJECTIVE:

To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios.

DESIGN:

Family-based study.

SETTING:

University hospital.

PATIENT(S):

A total of 224 unrelated PCOS probands, their biologic parents, and 204 control subjects.

INTERVENTION(S):

Anthropometric, hormonal, and metabolic assessment; genotype detection.

MAIN OUTCOME MEASURE(S):

Basic endocrine, serum fasting glucose (FG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels were measured. The transmission disequilibrium test (TDT) was used to analyze the association between two SNPs of ADIPOQ and PCOS.

RESULT(S):

A significant positive association was detected between SNP rs1501299 and PCOS. Compared with AA genotype, AC and CC genotypes had increased risk for PCOS, and the difference remained significant after adjustment for age, body mass index, and testosterone (T). The levels of T, TG, HDL cholesterol, and FINS were significantly higher in obese PCOS patients. However, we failed to find significant overtransmission of the other SNP, rs2241766, from parents to PCOS offspring. The genotype frequencies of rs2241766 and rs1501299 were not different in obese and lean PCOS patients and their parents.

CONCLUSION(S):

TDT confirms that SNP rs1501299 in the ADIPOQ is significantly associated with the risk of PCOS in the Chinese Han population. The present data may provide a basis for further studies of the role of the ADIPOQ in the etiology of PCOS.

Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

ADIPOQ; Polycystic ovary syndrome; single-nucleotide polymorphism; transmission disequilibrium test

PMID:
24559720
[PubMed - indexed for MEDLINE]
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