Spontaneous coronary artery dissection associated with β-HCG injections and fibromuscular dysplasia

Can J Cardiol. 2014 Apr;30(4):464.e1-3. doi: 10.1016/j.cjca.2013.11.030. Epub 2013 Dec 6.

Abstract

Spontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndrome predominantly affecting younger women. SCAD is often associated with predisposing arterial abnormalities and precipitating emotional, physical, and hormonal stressors. We previously showed that fibromuscular dysplasia is strongly associated with SCAD and may be a causative factor. Hormonal changes related to pregnancy and sex hormones have also been shown to be an important cause of SCAD. We describe the first case report, to our knowledge, of SCAD associated with β-human growth hormone injections in a patient with concomitant FMD.

Publication types

  • Case Reports

MeSH terms

  • Chest Pain / etiology
  • Chorionic Gonadotropin, beta Subunit, Human / administration & dosage
  • Chorionic Gonadotropin, beta Subunit, Human / adverse effects*
  • Coronary Angiography
  • Coronary Occlusion / diagnostic imaging
  • Coronary Vessels / injuries*
  • Female
  • Fibromuscular Dysplasia / complications*
  • Fibromuscular Dysplasia / diagnosis
  • Humans
  • Iliac Artery / diagnostic imaging
  • Injections, Intramuscular
  • Middle Aged
  • Renal Artery / diagnostic imaging
  • Renal Artery / injuries
  • Stroke Volume
  • Troponin T / blood
  • Weight Loss

Substances

  • Chorionic Gonadotropin, beta Subunit, Human
  • Troponin T