Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurosci. 2014 Feb 19;34(8):2910-20. doi: 10.1523/JNEUROSCI.3714-13.2014.

Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction.

Author information

  • 1Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454.

Abstract

Glial cells are emerging as important regulators of synapse formation, maturation, and plasticity through the release of secreted signaling molecules. Here we use chromatin immunoprecipitation along with Drosophila genomic tiling arrays to define potential targets of the glial transcription factor Reversed polarity (Repo). Unexpectedly, we identified wingless (wg), a secreted morphogen that regulates synaptic growth at the Drosophila larval neuromuscular junction (NMJ), as a potential Repo target gene. We demonstrate that Repo regulates wg expression in vivo and that local glial cells secrete Wg at the NMJ to regulate glutamate receptor clustering and synaptic function. This work identifies Wg as a novel in vivo glial-secreted factor that specifically modulates assembly of the postsynaptic signaling machinery at the Drosophila NMJ.

KEYWORDS:

Drosophila; NMJ; glia; synapse; wnt/Wg

PMID:
24553932
[PubMed - indexed for MEDLINE]
PMCID:
PMC3931504
Free PMC Article

Images from this publication.See all images (6)Free text

Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk