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Org Lett. 2014 Mar 7;16(5):1410-3. doi: 10.1021/ol500197x. Epub 2014 Feb 19.

Periconianone A, a new 6/6/6 carbocyclic sesquiterpenoid from endophytic fungus Periconia sp. with neural anti-inflammatory activity.

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  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China.

Abstract

Periconianone A (1), a polyoxygenated sesquiterpenoid with a new 6/6/6 tricarbocyclic skeleton, and periconianone B (2) were isolated from the endophytic fungus Periconia sp. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The biosynthesis of the unusual six-membered carbonic ring of 1 was postulated to be formed through intramolecular aldol condensation. Compounds 1 and 2 showed significant neural anti-inflammatory activity.

PMID:
24552610
[PubMed - indexed for MEDLINE]
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