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Molecules. 2014 Feb 17;19(2):2100-13. doi: 10.3390/molecules19022100.

Comparative evaluation of the radical-scavenging activities of fucoxanthin and its stereoisomers.

Author information

  • 1Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. zhangyiping310@163.com.
  • 2State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China. fangh6115@163.com.
  • 3State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China. XieQuanling@163.com.
  • 4State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China. sunjipeng80@163.com.
  • 5Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. cpulr@126.com.
  • 6State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China. xm_hzh@163.com.
  • 7State Oceanic Administration Third Institute of Oceanography, Xiamen 361005, Fujian, China. yiruizao@163.com.
  • 8Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China. whao5795@vip.sina.com.

Abstract

Fucoxanthin (Fuco) is a characteristic carotenoid of brown seaweeds. In the present study, Fuco and its stereoisomers 9'Z-Fuco, 13Z- and 13'Z-Fuco were extracted from Laminaria japonica Aresch. They were isolated and purified by silica gel column chromatography, Sephadex LH-20, and reversed-phase HPLC. The radical-scavenging activities of the three stereoisomers were evaluated toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical, hydroxyl radical, and superoxide radical. The order of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity was 13Z- and 13'Z-Fuco > (all-E)-Fuco > 9'Z-Fuco. The order of 2-2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and hydroxyl radical-scavenging activities were 9'Z-Fuco > (all-E)-Fuco > 13Z-and 13'Z-Fuco. The order of superoxide radical-scavenging activity was 13Z- and 13'Z-Fuco > (all-E)-Fuco > 9'Z-Fuco. The scavenging activities of Fuco and its stereoisomers toward the four radical types were all dose-dependent. The ABTS, DPPH, and superoxide radical-scavenging activities were all weaker than that of tocopherol (VE), while their hydroxyl radical-scavenging activities were stronger than that of VE. The results confirmed that Fuco and its stereoisomers have potent antioxidant activities.

PMID:
24549234
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