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Biomarkers. 2014 Mar;19(2):159-65. doi: 10.3109/1354750X.2014.891047. Epub 2014 Feb 19.

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

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  • 1Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University , New York, NY , USA .

Abstract

RATIONALE:

Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN.

METHODS:

Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.

RESULTS:

LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.

CONCLUSIONS:

Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.

PMID:
24548082
[PubMed - indexed for MEDLINE]
PMCID:
PMC4306444
Free PMC Article
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