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Lancet. 1988 Jun 11;1(8598):1295-8.

Phase I clinical trial of a World Health Organisation birth control vaccine.

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  • 1Department of Obstetrics and Gynaecology, Flinders Medical Centre, Adelaide, Australia.


A birth control vaccine incorporating a synthetic peptide antigen representing the aminoacid sequence 109-145 of the C-terminal region of the beta subunit of human chorionic gonadotropin (hCG-beta) was submitted to a phase 1 clinical trial. Thirty surgically sterilised female volunteers, divided into five equal groups for different vaccine doses, received two intramuscular injections six weeks apart. Over a six-month follow-up there were no important adverse reactions, and potentially contraceptive levels of antibodies to hCG developed in all subjects. In the highest vaccine dose group, the results gave promise of a contraceptive effect of six months' duration.

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