Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: a meta-analysis

Chen Cheng; Wang Lingyan; Huang Yi; Zhang Cheng; Ye Huadan; Xu Xuting; Xu Leiting; Ye Meng; Duan Shiwei

doi:10.1016/j.clinre.2013.12.009

Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: a meta-analysis

Clin Res Hepatol Gastroenterol. 2014 Jun;38(3):346-59. doi: 10.1016/j.clinre.2013.12.009. Epub 2014 Feb 16.

Authors

Chen Cheng¹, Wang Lingyan², Huang Yi³, Zhang Cheng⁴, Ye Huadan⁴, Xu Xuting⁴, Xu Leiting⁴, Ye Meng⁵, Duan Shiwei⁶

Affiliations

¹ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China; The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, China.
² Bank of Blood Products, Ningbo No.2 Hospital, Ningbo, Zhejiang 315010, China.
³ Department of Neurosurgery, Ningbo First Hospital, Ningbo University, Ningbo, Zhejiang 315010, China.
⁴ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
⁵ The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, China. Electronic address: yemeng@nbu.edu.cn.
⁶ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: duanshiwei@nbu.edu.cn.

PMID: 24534481
DOI: 10.1016/j.clinre.2013.12.009

Abstract

Objective: The aim of our meta-analyses is to test the association between six genetic polymorphisms and gastric cancer.

Methods: A systematic search was performed for all the available candidate genes and gastric cancer among several online databases including PubMed, Embase, Web of Science, the Cochrane Library, CNKI and Wanfang online libraries. After a comprehensive screening, a total of six genes were harvested for the current meta-analyses. These genes include TLR2 (-196 to -174 ins>del), MTR (rs1805087), MTRR (rs1801394), XPC (rs2228001), TP73 (G4C14-A4T14), and TP53 (rs1042522).

Results: Altogether 49 comparative studies among 11 776 cases and 18 633 controls were involved in our meta-analyses. TP53 rs1042522 polymorphism was shown to be associated with gastric cancer risk under the dominant model (P=0.02, OR=1.03, 95% CI=1.00-1.05). A subgroup meta-analysis indicated a significant association under dominant model between TP53 rs1042522 and gastric cancer in the Eastern Asians (P=0.03, OR=1.17, 95%=1.02-1.34).

Conclusions: These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics
DNA-Binding Proteins / genetics
Ferredoxin-NADP Reductase / genetics
Genetic Predisposition to Disease*
Humans
Nuclear Proteins / genetics
Polymorphism, Genetic*
Racial Groups / genetics
Stomach Neoplasms / genetics*
Toll-Like Receptor 2 / genetics
Tumor Protein p73
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Proteins / genetics

Substances

DNA-Binding Proteins
Nuclear Proteins
TLR2 protein, human
TP53 protein, human
TP73 protein, human
Toll-Like Receptor 2
Tumor Protein p73
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
XPC protein, human
methionine synthase reductase
Ferredoxin-NADP Reductase
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
MTR protein, human