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Atherosclerosis. 2014 Apr;233(2):387-93. doi: 10.1016/j.atherosclerosis.2014.01.010. Epub 2014 Jan 21.

Associations between γ-glutamyltransferase (GGT) and biomarkers of atherosclerosis: the Multi-ethnic Study of Atherosclerosis (MESA).

Author information

  • 1Bastyr University California, 4106 Sorrento Valley Blvd., San Diego, CA 92121, USA; University of Washington, USA. Electronic address: rbradley@bastyr.edu.
  • 2University of Washington, USA.
  • 3University of Minnesota, USA.
  • 4Kyungpook National University, Republic of South Korea.
  • 5University of Vermont, USA.
  • 6Wake Forest University, USA.

Abstract

OBJECTIVE:

To evaluate associations between total serum γ-glutamyltransferase activity (GGT) and biomarkers of arteriosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA), including 6783 participants from four ethnic subgroups, i.e., White, Chinese, Black and Hispanic.

METHODS:

Associations between fasting total serum GGT activity and oxidized low-density lipoproteins (oxLDL), interleukin-6 (IL-6), C-reactive protein (CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) were assessed. Following evaluation of linear trends between GGT and biomarkers of interest, multivariable linear regression models were serially adjusted for age, gender, site, ethnicity (M1); M1+lifestyle variables (M2); M2+traditional cardiovascular risk factors plus medications (M3); and M3+metabolic status (M4). Interactions were evaluated between GGT and age and ethnicity in all models.

RESULTS:

Linear trends were positive and significant between GGT and oxLDL, IL-6, CRP and sICAM-1 in crude models, and trends remained significant in all ethnic subgroups for CRP (p<0.0001) and sICAM-1 (p<0.001), and for IL-6 except in the Chinese. Trends between GGT and oxLDL were significant in the entire cohort and the White subgroup (p<0.0001), but not in other ethnic subgroups. Multivariable models demonstrated continuous strong, positive associations between GGT and CRP, IL-6 and sICAM-1. Associations between GGT and oxLDL were attenuated upon adjustment for LDL-C and other traditional risk factors. All models were attenuated with adjustment for metabolic status. No age interactions were evident.

CONCLUSIONS:

Our findings support the hypothesis that total serum GGT activity represents the impact of metabolic disease on vascular injury and atherosclerosis.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

CRP; Endothelial dysfunction; GGT; Oxidative stress; Oxidized LDL; sICAM

PMID:
24530768
[PubMed - indexed for MEDLINE]
PMCID:
PMC4000064
Free PMC Article
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