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Gene. 2014 Apr 15;539(2):275-8. doi: 10.1016/j.gene.2014.01.077. Epub 2014 Feb 12.

Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting.

Author information

  • 1Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: adrianedallanora@gmail.com.
  • 2Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: ac.tonet@uol.com.br.
  • 3Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: wilcellymachado@gmail.com.
  • 4Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil; Instituto de Cardiologia Biocardios, SEPS 709/909 Sul Edifício Biocenter, Asa Sul, 70.390-095 Brasília, DF, Brazil. Electronic address: wladimir.magalhaes@terra.com.br.
  • 5Instituto de Cardiologia Biocardios, SEPS 709/909 Sul Edifício Biocenter, Asa Sul, 70.390-095 Brasília, DF, Brazil. Electronic address: luizquaglia@gmail.com.
  • 6Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: sns2003@uol.com.br.
  • 7Universidade Católica de Brasília (UCB-DF), QS 07 Lote 01 EPCT, 71.966-700, Taguatinga, DF, Brazil. Electronic address: cordova@ucb.br.
  • 8Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil; Universidade Estadual de Campinas (UNICAMP), Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo 126, 13.083-887, Campinas, SP, Brazil. Electronic address: andreisposito@gmail.com.
  • 9Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: otavionobrega@unb.br.

Abstract

BACKGROUND:

Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes.

AIM:

We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile.

METHODS:

We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events.

RESULTS:

When non-ε4 carriers were compared with ε4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups.

CONCLUSION:

The study suggests a possible atherogenic role of the ε4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Aging; Apolipoprotein; Atherosclerosis; Lipid metabolism; Primary prevention

PMID:
24530308
[PubMed - indexed for MEDLINE]
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