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Biomed Pharmacother. 2014 Apr;68(3):259-65. doi: 10.1016/j.biopha.2013.12.009. Epub 2014 Jan 28.

Evaluation of Annexin A7, Galectin-3 and Gelsolin as possible biomarkers of hepatocarcinoma lymphatic metastasis.

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  • 1Department of Pathology, Dalian Medical University, Key Laboratory of Tumor Metastasis of Liaoning Province University, 9, West Lvshun Southern Road, Dalian, 116044 Liaoning, China; Department of Pathology, Qiqihar Medical College, 161006 Heilongjiang, China.
  • 2Department of Pathology, Dalian Medical University, Key Laboratory of Tumor Metastasis of Liaoning Province University, 9, West Lvshun Southern Road, Dalian, 116044 Liaoning, China.
  • 3Department of Human Anatomy, Dalian Medical University, 9, West Lvshun Southern Road, Dalian, 116044 Liaoning, China.
  • 4Department of Pathology, Dalian Medical University, Key Laboratory of Tumor Metastasis of Liaoning Province University, 9, West Lvshun Southern Road, Dalian, 116044 Liaoning, China. Electronic address: jwtang_53@sina.cn.

Abstract

We have previously demonstrated that Annexin A7 is involved in the lymphatic metastasis of hepatocarcinoma in vitro. The expression of Galectin-3 and Gelsolin, which were also relevant to tumor lymphatic metastasis, had shown the same tendency concordantly with the expression of Annexin A7 alteration by qRT-PCR and Western blot analysis. Here, we gain an insight into the role that Annexin A7 is playing in Hca-P, PAnxa7-upregulated and PAnxa7-downregulated cells in vivo. Then, Hca-P, PAnxa7-upregulated and PAnxa7-downregulated cells were injected into a mouse footpad to establish primary tumors in mice. On the fourth week after HCC cells inoculation, the mice were sacrificed for inspection the expression of Annexin A7, Galectin-3 and Gelsolin in primary tumors and in serum. Our work indicates that Annexin A7 and Gelsolin are both valuable in tumors and in serum evaluating lymph node metastasis in mice with hepatocarcinoma; Galectin-3 in tumors is significant but no much contribution in serum.

Copyright © 2014 Elsevier Masson SAS. All rights reserved.

KEYWORDS:

Animal experiment; Annexin A7 (ANXA7 or synexin); Lymphatic metastasis; Metastasis associated biomarkers

PMID:
24529848
[PubMed - in process]
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