[Safe prescription recommendations for non steroidal anti-inflammatory drugs: Consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)]

Gastroenterol Hepatol. 2014 Mar;37(3):107-27. doi: 10.1016/j.gastrohep.2013.11.014. Epub 2014 Feb 14.
[Article in Spanish]

Abstract

This article outlines key recommendations for the appropriate prescription of non steroidal anti-inflammatory drugs to patients with different musculoskeletal problems. These recommendations are based on current scientific evidence, and takes into consideration gastrointestinal and cardiovascular safety issues. The recommendations have been agreed on by experts from three scientific societies (Spanish Society of Rheumatology [SER], Spanish Association of Gastroenterology [AEG] and Spanish Society of Cardiology [SEC]), following a two-round Delphi methodology. Areas that have been taken into account encompass: efficiency, cardiovascular risk, gastrointestinal risk, liver risk, renal risk, inflammatory bowel disease, anemia, post-operative pain, and prevention strategies. We propose a patient management algorithm that summarizes the main aspects of the recommendations.

Keywords: Adverse event; Anti-inflamatorios no esteroideos; Cardiovascular; Efecto adverso; Gastrointestinal hemorrhage; Hemorragia gastrointestinal; Non steroidal anti-inflammatory drugs; Peptic ulcer; Úlcera péptica.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Age Factors
  • Algorithms
  • Anemia / chemically induced
  • Anemia / prevention & control
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Anticoagulants / pharmacology
  • Anticoagulants / therapeutic use
  • Cardiovascular Diseases / chemically induced
  • Cardiovascular Diseases / prevention & control
  • Chemical and Drug Induced Liver Injury / etiology
  • Chemical and Drug Induced Liver Injury / prevention & control
  • Drug Interactions
  • Gastrointestinal Hemorrhage / chemically induced
  • Gastrointestinal Hemorrhage / prevention & control
  • Humans
  • Kidney Diseases / chemically induced
  • Kidney Diseases / prevention & control
  • Meta-Analysis as Topic
  • Pain, Postoperative / drug therapy
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / prevention & control
  • Peptic Ulcer Hemorrhage / chemically induced
  • Peptic Ulcer Hemorrhage / prevention & control
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use
  • Quality of Life
  • Rheumatic Diseases / drug therapy
  • Risk Assessment

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticoagulants
  • Platelet Aggregation Inhibitors