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Atherosclerosis. 2014 Mar;233(1):260-7. doi: 10.1016/j.atherosclerosis.2013.12.037. Epub 2014 Jan 18.

Association of the triglycerides to high-density lipoprotein cholesterol ratio with the risk of chronic kidney disease: analysis in a large Japanese population.

Author information

  • 1Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tsuruya@intmed2.med.kyushu-u.ac.jp.
  • 2Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: hisako@kcu.med.kyushu-u.ac.jp.
  • 3Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: masanaga@envmed.med.kyushu-u.ac.jp.
  • 4Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kitazono@intmed2.med.kyushu-u.ac.jp.
  • 5Division of Nephrology and Dialysis Center, Japanese Red Cross Fukuoka Hospital, 3-1-1 Okusu, Minami-ku, Fukuoka 815-8555, Japan. Electronic address: hhirakata@fukuoka-med.jrc.or.jp.
  • 6Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: chihokun@med.u-ryukyu.ac.jp.
  • 7Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: moriyama@wellness.hss.osaka-u.ac.jp.
  • 8Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: k-yamaga@md.tsukuba.ac.jp.
  • 9Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: yoshihi@sapmed.ac.jp.
  • 10Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: fujimos@fc.miyazaki-u.ac.jp.
  • 11Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: asahi@fmu.ac.jp.
  • 12Department of Planning, Information, and Management, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kurahashi@epistat.m.u-tokyo.ac.jp.
  • 13Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: ohashi@epistat.m.u-tokyo.ac.jp.
  • 14Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: twat0423@fmu.ac.jp.

Abstract

OBJECTIVES:

To investigate the relationship between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and chronic kidney disease (CKD).

METHODS:

We used data from 216,007 Japanese adults who participated in a nationwide health checkup program. Men (n = 88,516) and women (n = 127,491) were grouped into quartiles based on their TG/HDL-C levels (<1.26, 1.26-1.98, 1.99-3.18, and >3.18 in men; <0.96, 0.96-1.44, 1.45-2.22, and >2.22 in women). We cross-sectionally assessed the association of TG/HDL-C levels with CKD [defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2) (low eGFR) and/or proteinuria (defined as urinary protein ≥ 1+ on dipstick testing)], low eGFR, and proteinuria.

RESULTS:

The prevalence of CKD, low eGFR, and proteinuria increased significantly with elevating quartiles of TG/HDL-C in both genders (all P for trend <0.001). Participants in the highest quartile of TG/HDL-C had a significantly greater risk of CKD than those in the lowest quartile after adjustment for the relevant confounding factors (odds ratio: 1.57, 95% confidence interval: 1.49-1.65 in men; 1.41, 1.34-1.48 in women, respectively). Furthermore, there were significant associations with low eGFR and proteinuria. In stratified analysis, the risk of CKD increased linearly with greater TG/HDL-C levels in participants with and without hypertension, diabetes, and obesity. Moreover, higher TG/HDL-C levels were relevant for CKD, especially in participants with hypertension and diabetes (P for interaction <0.001, respectively).

CONCLUSIONS:

An elevated TG/HDL-C is associated with the risk of CKD in the Japanese population.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Chronic kidney disease; Diabetes; Hypertension; Japanese population; Triglycerides to high-density lipoprotein cholesterol ratio

PMID:
24529154
[PubMed - in process]
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