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Environ Res. 2014 Feb;129:27-31. doi: 10.1016/j.envres.2013.12.003. Epub 2014 Jan 11.

Circulating levels of p,p'-DDE are related to prevalent hypertension in the elderly.

Author information

  • 1Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Ulleråkersvägen 40, 751 85 Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
  • 2Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Ulleråkersvägen 40, 751 85 Uppsala, Sweden.
  • 3MTM Research Center, School of Science and Technology, Örebro University, Örebro, Sweden.
  • 4Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.

Abstract

BACKGROUND:

Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women.

METHODS:

One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure ≥140mmHg or a diastolic blood pressure ≥90mmHg, and/or use of antihypertensive medication.

RESULTS:

Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 1.35 for a 1 SD change, 95% CI 1.17-1.56, p<0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006).

CONCLUSION:

In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

DDE; Elderly; Hypertension; Persistent organic pollutants; Polychlorinated biphenyls

PMID:
24528999
[PubMed - indexed for MEDLINE]
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