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Intern Med J. 2014 Feb;44(2):195-7. doi: 10.1111/imj.12343.

Intravenous thrombolysis is unsafe in stroke due to infective endocarditis.

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  • 1Department of Neurology, Auckland City Hospital, Auckland, New Zealand.


Embolic stroke is the most common neurological complication of infective endocarditis and a major source of morbidity and mortality. Septic embolism is considered a contraindication to intravenous thrombolysis in patients with ischaemic stroke because of concerns over an increased risk of intracranial haemorrhage. We describe a patient with occult endocarditis who was treated with thrombolysis for acute stroke and review other cases reported in the literature.

© 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.


infective endocarditis; stroke; thrombolysis

[PubMed - indexed for MEDLINE]
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