Send to:

Choose Destination
See comment in PubMed Commons below

[The over-expression of STAT1 and IFN-gamma in lesions of human oral lichen planus].

[Article in Chinese]

Author information

  • 1Deptment of Stomatology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.



To understand the possible role of signal transducer and activator of transcription 1 (STAT1) and interferon-gamma (IFN-gamma) in the generation of local lesions of oral lichen planus (OLP).


Formalin-fixed, paraffin-embedded tissues of 10 cases of normal oral epithelium and 48 cases of OLP were investigated for STAT1 and IFN-gamma proteins by using immunohistochemistry SABC method. The correlation between the expression of STAT1 and IFN-gamma proteins and the clinical and pathological characteristics in OLP were statistically analyzed.


(1) STAT1 and IFN-gamma were over expressed compared with healthy oral mucosa (P < 0.05). (2) The percentage of STAT1 over-expression in OLP with positive IFN-gamma staining was significantly higher than that in OLP with negative IFN-gamma staining (chi2 = 5.042, P < 0.05). A positive correlation between the over-expression of STAT1 and IFN-gamma was seen in OLP (r = 0.324, P < 0.05). (3) The percentage of over-expression of STAT1 in OLP with disease course less than 6 months was higher than that in OLP with disease course more than 6 months (chi2 = 5.077, P < 0.05), and a positive correlation was observed between the over-expression of IFN-gamma and the liquefaction of base cells in local lesions of OLP (r = -0.388, P < 0.05).


The over-expression of STAT1 and IFN-gamma may participate in the generation of local pathological damnification of OLP at the early stage.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk