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Cancer Genet. 2014 Jan-Feb;207(1-2):35-9.e1-2. doi: 10.1016/j.cancergen.2013.12.002. Epub 2014 Jan 3.

Replication of results of a genome-wide association study on lung cancer survival in a Korean population.

Author information

  • 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea; Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea.
  • 2Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
  • 3Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
  • 4Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
  • 5Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
  • 6Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Thoracic Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
  • 7Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea; Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. Electronic address: jaeyong@knu.ac.kr.

Abstract

Recently, a genome-wide association study (GWAS) identified single nucleotide polymorphisms (SNPs) that may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS on lung cancer survival in a Korean population. A total of 363 patients with surgically resected NSCLCs were enrolled, and 12 SNPs were genotyped using the SEQUENOM MassARRAY iPLEX assay, TaqMan assay, or a polymerase chain reaction-restriction fragment length polymorphism analysis. The association between genotypes and overall survival (OS) was analyzed. Among the 12 SNPs, the rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed a better OS than the patients with the rs6034368T allele (adjusted hazard ratio = 0.72, confidence interval = 0.56-0.93, P = 0.01). The rs12446308A>G had an effect on OS, but it was marginally significant (under a codominant model, adjusted hazard ratio = 1.85, confidence interval = 0.98-3.47, P = 0.06). We identified that the rs6034368T>C was associated with survival in early-stage NSCLC in a Korean population.

Copyright © 2014. Published by Elsevier Inc.

KEYWORDS:

Genome-wide association study; non-small cell lung cancer; polymorphism; survival

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