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Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2988-91. doi: 10.1002/anie.201310060. Epub 2014 Feb 12.

Total synthesis of the Isodon diterpene sculponeatin N.

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  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208 (USA).


The total synthesis of sculponeatin N, a bioactive polycyclic diterpene isolated from Isodon sculponeatus, is reported. Key features of the synthesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficient formation of the bicyclo[3.2.1]octane ring system by a reductive radical cyclization.

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


isodon terpenes; natural products; reductive cyclization; ring-closing metathesis

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