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Chem Commun (Camb). 2014 Apr 14;50(29):3789-91. doi: 10.1039/c4cc00016a. Epub 2014 Feb 12.

Dual responsive supramolecular nanogels for intracellular drug delivery.

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  • 1Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.


Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.

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