Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Hum Genet. 2014 Oct;22(10):1208-16. doi: 10.1038/ejhg.2013.310. Epub 2014 Feb 12.

Genetic ancestry is associated with colorectal adenomas and adenocarcinomas in Latino populations.

Author information

  • 11] Grupo de Investigacion Epidemiologica, Instituto Nacional de Cancerologia de Colombia, Bogota, Colombia [2] The Roslin Institute, The University of Edinburgh, Edinburgh, UK.
  • 21] Grupo de Investigacion Epidemiologica, Instituto Nacional de Cancerologia de Colombia, Bogota, Colombia [2] Departamento de Quimica, Universidad Nacional de Colombia, Cundinamarca, Colombia.
  • 3Facultad de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia.
  • 4Facultad de Medicina, Universidad Libre, Barranquilla, Colombia.
  • 5Fundacion Oftalmologica de Santander, Bucaramanga, Colombia.
  • 6Department of Pediatrics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
  • 71] The Roslin Institute, The University of Edinburgh, Edinburgh, UK [2] MRC-Human Genetics Unit at the MRC IGMM, University of Edinburgh, Edinburgh, UK.


Colorectal cancer rates in Latin American countries are less than half of those observed in the United States. Latin Americans are the resultant of generations of an admixture of Native American, European, and African individuals. The potential role of genetic admixture in colorectal carcinogenesis has not been examined. We evaluate the association of genetic ancestry with colorectal neoplasms in 190 adenocarcinomas, 113 sporadic adenomas and 243 age- and sex-matched controls enrolled in a multicentric case-control study in Colombia. Individual ancestral genetic fractions were estimated using the STRUCTURE software, based on allele frequencies and assuming three distinct population origins. We used the Illumina Cancer Panel to genotype 1,421 sparse single-nucleotide polymorphisms (SNPs), and Northern and Western European ancestry, LWJ and Han Chinese in Beijing, China populations from the HapMap project as references. A total of 678 autosomal SNPs overlapped with the HapMap data set SNPs and were used for ancestry estimations. African mean ancestry fraction was higher in adenomas (0.13, 95% confidence interval (95% CI)=0.11-0.15) and cancer cases (0.14, 95% CI=0.12-0.16) compared with controls (0.11, 95% CI=0.10-0.12). Conditional logistic regression analysis, controlling for known risk factors, showed a positive association of African ancestry per 10% increase with both colorectal adenoma (odds ratio (OR)=1.12, 95% CI=0.97-1.30) and adenocarcinoma (OR=1.19, 95% CI=1.05-1.35). In conclusion, increased African ancestry (or variants linked to it) contributes to the increased susceptibility of colorectal cancer in admixed Latin American population.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk