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Eur J Microbiol Immunol (Bp). 2011 Sep;1(3):208-14. doi: 10.1556/EuJMI.1.2011.3.4. Epub 2011 Sep 9.

In vitro induced CD8+ regulatory T cells inhibit skin inflammation.

Abstract

CD8(+) regulatory T cells appear impaired in number and/or function in some autoimmune diseases. However, the role of CD8(+) regulatory T cells in the pathogenesis of skin inflammation and psoriasis remains unknown. In this study, we set out to analyze the capability of CD8(+) regulatory T cells to inhibit skin inflammation in a murine model and to determine the frequency of CD8(+) regulatory T cells in patients with psoriasis. We demonstrate that murine fully competent CD8(+) regulatory T cells can be induced by stimulating naïve CD8(+) T cells in the presence of TGF-β and retinoic acid (RA). Importantly, in vitro induced CD8(+) regulatory T cells significantly suppressed skin inflammation in vivo. Furthermore, we found that the frequency of regulatory CD8(+)CD25(+)Foxp3(+) T cells is decreased in peripheral blood but increased in lesional psoriatic skin of patients with psoriasis. Thus, our study suggests a previously unappreciated role of CD8(+)CD25(+)Foxp3(+) T cells in skin disorders, and induction of these cells in vitro may be an effective immunotherapy for skin inflammation.

KEYWORDS:

CD8+ T cells; immune modulation; immune regulation; skin inflammation

PMID:
24516726
[PubMed]
PMCID:
PMC3906616
Free PMC Article
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