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FEBS Lett. 2013 Oct 25. pii: S0014-5793(13)00780-1. doi: 10.1016/j.febslet.2013.10.023. [Epub ahead of print]

Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1.

Author information

  • 1Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China.
  • 2Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China.
  • 3Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China. Electronic address: gytbdyy@163.com.
  • 4Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China. Electronic address: caizhiming2011@163.com.

Abstract

MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/ oncogenic long noncoding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic downregulated, whereas hsa-miR-125b inhibitor upregulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of upregulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.

Copyright © 2013. Published by Elsevier B.V.

KEYWORDS:

Bladder cancer; Hsa-miR-125b; Long noncoding RNA; MALAT1; Microrna; SIRT7

PMID:
24512851
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