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J Pediatr (Rio J). 2014 May-Jun;90(3):221-31. doi: 10.1016/j.jped.2013.08.012. Epub 2014 Feb 6.

Late prematurity: a systematic review.

Author information

  • 1Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: machado_maria@uol.com.br.
  • 2Department of Obstetrics and Gynecology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
  • 3Neonatology Division of the Department of Pediatrics, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.

Abstract

OBJECTIVE:

this study aimed to review the literature regarding late preterm births (34 weeks to 36 weeks and 6 days of gestation) in its several aspects.

SOURCES:

the MEDLINE, LILACS, and Cochrane Library databases were searched, and the references of the articles retrieved were also used, with no limit of time.

DATA SYNTHESIS:

numerous studies showed a recent increase in late preterm births. In all series, late preterm comprised the majority of preterm births. Studies including millions of births showed a strong association between late preterm birth and neonatal mortality. A higher mortality in childhood and among young adults was also observed. Many studies found an association with several neonatal complications, and also with long-term disorders and sequelae: breastfeeding problems, cerebral palsy, asthma in childhood, poor school performance, schizophrenia, and young adult diabetes. Some authors propose strategies to reduce late preterm birth, or to improve neonatal outcome: use of antenatal corticosteroids, changes in some of the guidelines for early delivery in high-risk pregnancies, and changes in neonatal care for this group.

CONCLUSIONS:

numerous studies show greater mortality and morbidity in late preterm infants compared with term infants, in addition to long-term disorders. More recent studies evaluated strategies to improve the outcomes of these neonates. Further studies on these strategies are needed.

Copyright © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

KEYWORDS:

Early neonatal mortality; Gravidez de alto risco; High-risk pregnancy; Infant mortality; Mortalidade infantil; Mortalidade neonatal; Mortalidade neonatal precoce; Neonatal mortality; Preterm labor; Trabalho de parto prematuro

PMID:
24508009
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