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Asian Pac J Trop Med. 2014 Apr;7(4):262-6. doi: 10.1016/S1995-7645(14)60034-1.

Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells.

Author information

  • 1Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 250031, China.
  • 2Department of Neurology, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
  • 3Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
  • 4Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 250031, China. Electronic address: woaifei371328@163.com.

Abstract

OBJECTIVE:

To evaluate of the curative effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on rat acute radiation pneumonitis.

METHODS:

Fourty rats were randomly divided into control group, radiation group, stem cell prevention group, stem cell treatment group and prednisone treatment group. All rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage model. The hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein (1×10(6) cells/kg BW) 24 h before the radiation, while the same administration was performed in the rats of the treatment group 24 h after the radiation. After 24 h post the radiation, the rats in the radiation group were given 0.4 mL physiological saline, and those in the prednisone group were given 1 mg/kg prednisone. All rats were observed and executed 72 h after the radiation to detect lung histological changes.

RESULTS:

After the administration of hUC-MSCs, the survival status of the rats in the prevention group and treatment group was obviously better than that in the control group. As shown by the histological staining, the morphology, proliferation activity and bronchial state of lung tissues were better in the prevention group and treatment group than in the control group.

CONCLUSIONS:

The hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats.

Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

KEYWORDS:

Human umbilical cord mesenchymal stem cell; Radiation pneumonitis; Rat

PMID:
24507672
[PubMed - in process]
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