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Carbohydr Polym. 2014 Feb 15;102:691-8. doi: 10.1016/j.carbpol.2013.10.101. Epub 2013 Nov 8.

Magnetic core-shell chitosan nanoparticles: rheological characterization and hyperthermia application.

Author information

  • 1Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain.
  • 2Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain; CIBER-BBN, Ebro River Campus Building R&D Block 5, Floor 1, Poeta Mariano Esquillor s/n, 50017 Zaragoza, Spain.
  • 3Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor, 50018 Zaragoza, Spain.
  • 4Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain. Electronic address: rhernandez@ictp.csic.es.

Abstract

Stabilized magnetic nanoparticles are the subject of intense research for targeting applications and this work deals with the design, preparation and application of specific core-shell nanoparticles based on ionic crosslinked chitosan. The nanometric size of the materials was demonstrated by dynamic light scattering (DLS) and field emission scanning electron microscopy (FESEM) that also proved an increase of the size of chitosan nanoparticles (NPs) with the magnetite content. Steady oscillatory rheology measurements revealed a gel-like behavior of aqueous dispersions of chitosan NPs with concentrations ranging from 0.5% to 2.0% (w/v). The cytotoxicity of all the materials synthesized was analyzed in human fibroblasts cultures using the Alamar Blue and lactate dehydrogenase (LDH) assays. The measured specific power absorption under alternating magnetic fields (f = 580 kHz, H = 24 kA/m) indicated that magnetic core-shell chitosan NPs can be useful as remotely driven heaters for magnetic hyperthermia.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Chitosan; Core–shell nanoparticles; Magnetic hyperthermia; Sodium tripolyphosphate

[PubMed - indexed for MEDLINE]
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