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Carbohydr Polym. 2014 Feb 15;102:238-45. doi: 10.1016/j.carbpol.2013.11.040. Epub 2013 Dec 4.

Preparation, characterization and cytotoxicity of schizophyllan/silver nanoparticle composite.

Author information

  • 1Central European Institute of Technology (CEITEC), Brno University of Technology, Brno Czech Republic; Textile Research Division, National Research Center, Dokki, P.O. 12622, Giza 12522, Egypt. Electronic address: abdel-mohsen@ceitec.vutbr.cz.
  • 2Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Czech Republic.
  • 3Chemistry Department, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia; Textile Research Division, National Research Center, Dokki, P.O. 12622, Giza 12522, Egypt. Electronic address: m_gaballa@yahoo.com.
  • 4Central European Institute of Technology (CEITEC), Brno University of Technology, Brno Czech Republic.
  • 5Institute of Materials Chemistry, Brno University of Technology, Czech Republic.
  • 6Chemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt.
  • 7Chemistry Department, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.
  • 8Chemistry Department, Faculty of Science, Fayoum University, Fayoum, Egypt.
  • 9Central European Institute of Technology (CEITEC), Brno University of Technology, Brno Czech Republic; Institute of Materials Chemistry, Brno University of Technology, Czech Republic.

Abstract

Silver nanoparticles (Ag-NPs) have been successfully prepared with a simple and "green" chemical reduction method. Triple helical schizophyllan (SPG) was used for the first time as reducing and stabilizing agents. The effect of temperature, silver nitrate/schizophyllan concentrations, pH of the reactions medium and the reaction time were investigated. The obtained schizophyllan/Ag-NP was characterized by UV-vis spectroscopy, TEM, DLS, X-ray diffraction, TGA, and ATR-FTIR. The results revealed that, Ag-NPs attached to SPG through a strong non-covalent interaction, leading to good dispersion of Ag-NPs with a diameter of 6 nm within the biopolymer matrix. By increasing the pH of the reaction medium, the triple helical structure of SPG was partially broken. The SPG/AgNP nanocomposite was non-toxic for mouse fibroblast line (NIH-3T3) and human keratinocyte cell line (HaCaT).

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Cytotoxicity; Green synthesis; Schizophyllan; Silver nanoparticles

PMID:
24507278
[PubMed - indexed for MEDLINE]
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