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Adv Immunol. 2014;122:211-52. doi: 10.1016/B978-0-12-800267-4.00006-7.

Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.

Author information

  • 1Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • 2Division of General Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, USA.
  • 3Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • 4Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • 5Department of Infectious Disease, Immunology, and Sexual Health, The St. George Hospital, University of New South Wales, Kogarah, New South Wales, Australia.
  • 6Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: rstevens@rics.bwh.harvard.edu.

Abstract

Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of their granule serine proteases in inflammation and the connective tissue remodeling that occurs during the different phases of the healing process of wounded skin and other organs. The accumulated data suggest that MCs, their tryptases, and their chymases play important roles in tissue repair. While MCs initially promote healing, they can be detrimental if they are chronically stimulated or if too many MCs become activated at the same time. The possibility that MCs and their granule serine proteases contribute to the formation of keloid and hypertrophic scars makes them potential targets for therapeutic intervention in the repair of damaged skin.

© 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Chymase; Connective tissue remodeling; Inflammation; Mast cell; Matrix metalloproteinase; Serine protease; Tryptase; Wound healing

PMID:
24507159
[PubMed - indexed for MEDLINE]
PMCID:
PMC4115062
Free PMC Article
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