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J Perinatol. 2014 Apr;34(4):311-8. doi: 10.1038/jp.2014.12. Epub 2014 Feb 6.

Evaluating retinopathy of prematurity screening guidelines for 24- to 27-week gestational age infants.

Collaborators (290)

Jobe AH, Caplan MS, Oh W, Vohr BR, Hensman AM, Stephens BE, Alksninis B, Andrews D, Angela K, Barnett S, Cashore B, Caskey M, Francis K, Gingras D, Gargus RA, Johnson K, Lainwala S, Leach TM, Leonard MR, Lillie S, Mehta K, Moore JR, Noel L, Ventura S, Walden RV, Watson VE, Fanaroff AA, Wilson-Costello DE, Siner BS, Zadell A, DiFiore J, Bhola M, Friedman HG, Yalcinkaya G, Donovan EF, Narendran V, Yolton K, Bridges K, Alexander B, Grisby C, Mersmann MW, Mincey HL, Hessling J, Gratton TL, Goldberg RN, Cotten CM, Goldstein RF, Ashley P, Auten KJ, Fisher KA, Foy KA, Freedman SF, Gustafson KE, Lohmeyer MB, Malcolm WF, Wallace DK, Stoll BJ, Buchter S, Piazza AJ, Carlton DP, Adams- Chapman I, Black L, Blackwelder AM, Carter S, Dinkins E, Fritz S, Hale EC, Hutchinson AK, LaRossa MM, Smikle GV, Poindexter BB, Dusick AM, Lemons JA, Wilson LD, Hamer F, Cook AB, Herron DE, Lytle C, Minnich HM, Berberich MA, Blaisdell CJ, Gail DB, Kiley JP, Poole WK, Newman JE, Hastings BK, Auman JO, Huitema CP, Pickett JW 2nd, Wallace D, Zaterka-Baxter KM, Van Meurs KP, Stevenson DK, Hintz SR, Epi MS, Ball MB, Bentley B, Bruno EF, Davis AS, DeAnda ME, DeBattista AM, Kohn JG, Proud MS, Pyle RP, St John NH, Weiss HE, Frantz ID 3rd, McGowan EC, Fiascone JM, Furey A, MacKinnon BL, Nylen E, Brussa A, Sibley C, Ambalavanan N, Peralta-Carcelen M, Collins MV, Cosby SS, Phillips VA, Bailey KJ, Biasini FJ, Hopkins M, Johnston KC, Krzywanski S, Nelson KG, Patterson CS, Rector RV, Rodriguez L, Soong A, Whitley S, York S, Rasmussen MR, Wozniak PR, Vaucher YE, Rich W, Arnell K, Barbieri-Welge R, Ben-Tall A, Bridge R, Demetrio C, Fuller MG, Ito E, Lukasik M, Pontillo D, Posin D, Runyan C, Wilkes J, Zlotnik P, Bell EF, Widness JA, Acarregui MJ, Klein JM, Colaizy TT, Johnson KJ, Eastman DL, Duara S, Bauer CR, Everett-Thomas R, Calejo M, Diaz AN, Eguaras SM, Garcia A, Hamlin-Smith K, Berkowits MH, Hiriart-Fajardo S, Mathews EO, Pierre H, Riguard A, Stroerger A, Watterberg KL, Ohls RK, Fuller J, Rohr J, Lacy CB, Lowe J, Montman R, Laroia N, Markowitz GD, Myers GJ, Reubens LJ, Hust D, Augostino L, Johnson JB, Burnell E, Jensen RL, Kushner E, Merzbach J, Yost K, Sánchez PJ, Rosenfeld CR, Salhab WA, Heyne RJ, Adams SS, Allen J, Grau L, Guzman A, Hensley G, Heyne ET, Lepps MH, Madden LA, Martin M, Miller NA, Morgan JS, Solis A, Torres LE, Boatman CT, Vasil DM, Wilder K, Tyson JE, Evans PW, Alaniz NI, Evans P, Harris BF, Green C, Jiminez M, Lis AE, Martin S, McDavid GE, Morris BH, Poundstone ML, Reddoch S, Siddiki S, Tate PL, Whitely LL, Wright SL, Bodnar A, Baker S, Bird K, Burnett J, Cole L, Osborne KA, Spencer C, Steffens M, Weaver-Lewis K, Zanetti K, O' Shea TM, Dillard RG, Washburn LK, Peters NJ, Jackson BG, Chiu K, Allred DE, Goldstein DJ, Halfond R, Peterson C, Waldrep EL, Welch CD, Morris MW, Hounshell GW, Shankaran S, Sood BG, Pappas A, Bara R, Billian E, Goldston LA, Johnson M, Ehrenkranz RA, Bhandari V, Jacobs HC, Cervone P, Gettner P, Konstantino M, Poulsen J, Taft J, Butler CG, Close N, Gilliam W, Greisman S, Romano E, Williams J, Avery G, Gleason CA, Allen MC, Bangdiwala SI, Blaisdell CJ, Boyle RJ, Clemons T, D' Alton ME, Gail DB, Hunt C, Keszler M, Redmond CK, Ross MG, Thomson MA, Weiner SJ, Willinger M, Markowitz GD, Hutchinson AK, Wallace DK, Freedman SF.

Author information

  • 1Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA.
  • 2Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
  • 3Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • 4Department of Pediatrics, University of California at San Diego, San Diego, CA, USA.
  • 5Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • 6Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
  • 7Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.
  • 8Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • 9Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA.
  • 10Biostatistics and Epidemiology Division, RTI International, Rockville, MD, USA.
  • 11Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.

Abstract

OBJECTIVE:

To determine whether current retinopathy of prematurity (ROP) screening guidelines adequately identify treatable ROP in a contemporary cohort of extremely low gestation infants.

STUDY DESIGN:

Data from the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial were used. Inborn infants of 24 (0)/7 to 27 (6)/7 weeks gestational age (GA) with consent before delivery were enrolled in 2005 to 2009. Severe ROP (type 1 ROP or treatment with laser, cryotherapy or bevacizumab) or death was the primary outcome for the randomized trial. Examinations followed the then current AAP (American Academy of Pediatrics) screening recommendations, beginning by 31 to 33 weeks postmenstrual age (PMA).

RESULT:

One thousand three hundred and sixteen infants were enrolled in the trial. Nine hundred and ninety-seven of the 1121 who survived to first eye exam had final ROP outcome determined. One hundred and thirty-seven (14% of 997) met criteria for severe ROP and 128 (93%) of those had sufficient data (without missing or delayed exams) to determine age of onset of severe ROP. PMA at onset was 32.1 to 53.1 weeks. In this referral center cohort, 1.4% (14/997) developed severe ROP after discharge.

CONCLUSION:

Our contemporary data support the 2013 AAP screening guidelines for ROP for infants of 24 (0)/7 to 27 (6)/7 weeks GA. Some infants do not meet treatment criteria until after discharge home. Post-discharge follow-up of infants who are still at risk for severe ROP is crucial for timely detection and treatment.

PMID:
24503911
[PubMed - indexed for MEDLINE]
PMCID:
PMC3969774
Free PMC Article
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