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Akush Ginekol (Sofiia). 2013;52(6):3-10.

[Impact of the multiple births on the postnatal blood count indices in premature infants].

[Article in Bulgarian]



To investigate the impact of the multiple births on the blood count indices in premature infants.


299 premature infants, born before 33rd gesta-tional week (GW), are investigated, divided in 2 groups according to the ges-tational age at birth (< or = 29 GW and 30-33 GW). These groups are divided addi-tionally in 2 subgroups: 1- singletons, and 2- twins. Hemoglobin (Hgb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular Hgb concentration (MCHC), peripheral reticulocytes (Ret) are examined at birth and in 27th, 30th, 33rd, 36th and 39th week corrected age (WCA).


The congenital infections are more often in group 1 of the newborns 5 29 GW. The twins 30th-33rd GW are with lower average weight and higher frequency of late blood transfusions. Comparing to singletons less mature twins are with initial higher levels of Hgb, Hct, MCV and lower levels of MCHC in 33rd and 36th WCA. They also show high-variable bone marrow answer with high levels of Ret in 30th, 33rd and 36th WCA. Initial values of Hgb, Hct are higher in more mature twins, MCHC also, but in 33rd and 39th WCA. Ret decrease permanently after elevation in 33rd WCA. The MCV levels are under the lower limit of normal in the both age groups.


The multiple births are risk factor for hematological condition in premature infants but the risk is proportional to the duration of the intrauterine stay.

[PubMed - indexed for MEDLINE]
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