Abstract
Of all the cytokines or growth factors that have been postulated to play a role in hair follicle, insulin-like growth factor-1 (IGF-1) is known to be regulated by androgens. However, how IGF-1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF-1 and its binding proteins by dermal papilla (DP) cells obtained from balding versus non-balding hair follicles were quantified using growth factor array. DP cells from balding scalp follicles were found to secrete significantly less IGF-1, IGFBP-2 and IGFBP-4 (P < 0.05) than their non-balding counterparts. Our data confirmed that the downregulation of IGF-1 may be one of the important mechanisms contributing to male pattern baldness.
Keywords:
IGF-1; androgenetic alopecia; hair follicle.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alopecia / metabolism*
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Cells, Cultured
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Hair Follicle / cytology
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Hair Follicle / metabolism*
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Humans
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Insulin-Like Growth Factor Binding Protein 1 / metabolism
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Insulin-Like Growth Factor Binding Protein 2 / metabolism
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Insulin-Like Growth Factor Binding Protein 3 / metabolism
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Insulin-Like Growth Factor Binding Protein 4 / metabolism
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Insulin-Like Growth Factor Binding Protein 6 / metabolism
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Insulin-Like Growth Factor Binding Proteins / metabolism*
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Insulin-Like Growth Factor I / metabolism*
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Male
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Middle Aged
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Scalp
Substances
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Insulin-Like Growth Factor Binding Protein 1
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Insulin-Like Growth Factor Binding Protein 2
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Insulin-Like Growth Factor Binding Protein 3
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Insulin-Like Growth Factor Binding Protein 4
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Insulin-Like Growth Factor Binding Protein 6
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Insulin-Like Growth Factor Binding Proteins
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Insulin-Like Growth Factor I