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Biochim Biophys Acta. 1987;895(1):1-10.

The proton pump ATPase of lysosomes and related organelles of the vacuolar apparatus.

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  • 1Dartmouth Medical School, Department of Biochemistry, Hanover, NH 03756.


In this review, I hope to achieve the following: (a) to document the presence of a lysosome-like proton pump ATPase in many different membrane systems of animal, plant and microbial origin; (b) to glean from the diverse data common characteristics of these ATPases, especially as regards their similarities and differences with mitochondrial-type F1F0 proton pump ATPases; and (c) to consider questions of synthesis and regulation of a cellular proton pump system with such a widespread distribution.

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