Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Clin Pharmacol. 1987 Dec;24(6):747-52.

Effects of silybin on histamine release from human basophil leucocytes.

Author information

  • 1Department of Internal Medicine, University of Milan, Ospedale Maggiore Policlinico, Italy.

Abstract

1. Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. 2. The f-met peptide and anti-IgE-induced histamine release was significantly (P less than 0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P greater than 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P less than 0.05) reversed by elevating extracellular calcium concentrations. 3. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.

PMID:
2449903
[PubMed - indexed for MEDLINE]
PMCID:
PMC1386399
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk